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5485

Optimum Contouring Method for Metabolic Tumor Volume Using PET/CT in Patients with Oral Cavity Squamous Cell Carcinoma

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Last updated: 03 Jan 2025

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Abstract

ABSTRACT:The metabolic tumor volume (MTV) is the volume of metabolically-active tumor on PET/CT. Although its potential clinical value has been investigated in many cancers, its routine use has been hampered by the delineation method used to calculate the tumor volume. This may be especially difficult for fuzzyPET images. Previous studies have used a lot of approaches for delineation of tumor volume; however, still there is no clear consensus on which method to be used, especially in the oral cavity region where the contouring may be difficult due to variable grades of physiological FDG uptake. Theaim of this study is to determine best contouring method for the metabolic tumor volume from PET/CT using different absolute and relative SUV values with correlation to the pathology. Materials and methods:We prospectively studied 126 patients with oral cavity squamous cell carcinoma (OCSCC) who underwent PET/CT before definitive treatment by radical surgery. The metabolic tumor volume (MTV) was calculated for the primary tumor according to absolute SUV figures (2.5, 3.0, 3.5 & 4.0) and fixed percentage of SUVmax (30%, 40%, 50%, 60% & 70%). Correlation between the axial diameters generated from these methods and the axial diameter from the fixed pathology specimens was used to determine the best of these methods. Results: Overall among the 9 contouring methods, absolute SUV 3.0 gave the best correlation (R = 0.723; P
< 0.001). Among the methods based on fixed percentage of SUVmax, a threshold of30% gave the best correlation (R =
0.701; P <0.001)
Conclusion: Contouring the metabolic tumor volume based on absolute SUV 3.0 can be used to represent the best correlation with pathologic data in patients with OCSCC.

DOI

10.21608/egyjnm.2012.5485

Keywords

Contouring, Tumor volume, Oral cavity Squamous cell carcinoma, Positron emission tomography computed tomography, Fluorodeoxyglucose

Authors

First Name

Yasser

Last Name

Abdelhafez

MiddleName

Gaber

Affiliation

Nuclear Medicine Unit, South Egypt Cancer Institute, Assuit University.

Email

yga1979@gmail.com

City

-

Orcid

0000-0002-1989-3094

First Name

Hosna

Last Name

Moustafa

MiddleName

-

Affiliation

Oncology and Nuclear Medicine Department, Kasr Al-Aini Hospital, Cairo University, Egypt.

Email

drhosna1947@gmail.com

City

-

Orcid

-

Volume

5

Article Issue

5

Related Issue

951

Issue Date

2012-06-01

Receive Date

2018-02-21

Publish Date

2012-06-01

Page Start

79

Page End

89

Print ISSN

1687-4994

Online ISSN

2536-9113

Article File

EGYJNM_Volume 5_Issue 5_Pages 79-89.pdf

PDF . 412.0kB

Link

https://egyjnm.journals.ekb.eg/article_5485.html

Detail API

https://egyjnm.journals.ekb.eg/service?article_code=5485

Order

8

Type

Original Paper, Physics

Type Code

387

Publication Type

Journal

Publication Title

Egyptian Journal Nuclear Medicine

Publication Link

https://egyjnm.journals.ekb.eg/

MainTitle

Optimum Contouring Method for Metabolic Tumor Volume Using PET/CT in Patients with Oral Cavity Squamous Cell Carcinoma

Details

Type

Article

Created At

22 Jan 2023