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5481

Role of 18F-FDG - PET/CT in Patients with Differentiated Thyroid Cancer Who Present with Elevated Thyroglobulin and Negative 131I Whole Body Scan

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Last updated: 03 Jan 2025

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Abstract

Aim of the work: To detect the ability of 18F-FDG with PET/CT to explain the elevated Tg levels in patients with negative 131I whole body diagnostic dose scan and to correlate of 18F-FDG with PET/CT with other diagnostic methods and histopathologic diagnosis.
Patients and methods: 20 patients (13 males and 7 females) with pathologicall proven differentiated cancer thyroid were included in the study. All patients were subjected to near total thyroidectomy. 8 out of the 20 patients also underwent lymph node dissection. All received 131I ablation and had a negative whole body scan during follow up. They had unexplained elevated (> 10 ng/ml or more) or rising serum Tg levels (5-10ng/ml). All patients were subjected to full history, clinical examination, Laboratory and radiological assessment as well as 18F-FDG PET/CT study.
Results: Neck US detected 7 lesions in 6 patients, all of them confirmed to be positive by PET/CT and an additional 13 neck lesions were detected by PET/CT in 15 patients. CT chest detected 8 patients, 6 of them confirmed by PET/CT while 2 lung lesions were negative. Eight additional mediastinal lymph node metastases were detected by PET/CT. PET/CT showed positive findings in 19/20 patients. In the remaining no cause for the elevated Tg was found with PET/CT or other radiological methods. PET/CT directed the management in 14/20 patients either to surgery or to external radiotherapy with normalization of Tg level within weeks after treatment.
Conclusion: 18F-FDG PET/CT is of undeniable clinical value in patients with negative 131I whole-body scan results who are suspected of having a metastatic thyroid disease. It is able to detect significantly additional tumor sites than US or CT procedures.

DOI

10.21608/egyjnm.2012.5481

Keywords

FDG PET/CT, Thyroglobuline, DCT, Iodine-WBS

Authors

First Name

Hosna

Last Name

Moustafa

MiddleName

-

Affiliation

Oncology and Nuclear Medicine Department, Kasr Al-Aini Hospital, Cairo University, Egypt.

Email

drhosna1947@gmail.com

City

-

Orcid

-

First Name

Khalid

Last Name

Taalab

MiddleName

-

Affiliation

Nuclear Medicine Consultant in El-Galaa Hospital & Maadi Armed Forced Hospital.

Email

ktaalab@gmail.com

City

-

Orcid

-

Volume

5

Article Issue

5

Related Issue

951

Issue Date

2012-06-01

Receive Date

2018-02-21

Publish Date

2012-06-01

Page Start

39

Page End

46

Print ISSN

1687-4994

Online ISSN

2536-9113

Article File

EGYJNM_Volume 5_Issue 5_Pages 39-46.pdf

PDF . 158.7kB

Link

https://egyjnm.journals.ekb.eg/article_5481.html

Detail API

https://egyjnm.journals.ekb.eg/service?article_code=5481

Order

4

Type

Original Paper, Oncology

Type Code

380

Publication Type

Journal

Publication Title

Egyptian Journal Nuclear Medicine

Publication Link

https://egyjnm.journals.ekb.eg/

MainTitle

Role of 18F-FDG - PET/CT in Patients with Differentiated Thyroid Cancer Who Present with Elevated Thyroglobulin and Negative 131I Whole Body Scan

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Type

Article

Created At

22 Jan 2023