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Role of 18F- FDG-PET/CT in Restaging of Breast Cancer Patients with High Tumour Markers and Equivocal Radiological Imaging

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Last updated: 03 Jan 2025

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Abstract

Objective: We aimed to assess the role of FDG PET/CT in detection of tumor recurrence in breast cancer patients with raised serum tumor markers and/or negative or equivocal abnormalities detected in other diagnostic imaging modalities. Patients and Methods: This prospective study was done on 100 previously diagnosed and treated breast cancer patients, All of patients referred for FDG-PET/CT scans in view of increased their serum tumour markers and/or equivocal abnormalities in other diagnostic imaging modalities. Clinical follow-up, tumour markers, conventional imaging modalities and FDG-PET/CT whole body scan was performed for each patient. Results: PET/CT detected recurrence and/or metastases in 63 out of 100 patients, including 23 loco-regional recurrence, 11 solitary organ involvement, 29 multiple organ involvement, whereas, other radiological modalities detected lesions in only 51 patients, those were 12 loco-regional recurrence, 24 solitary organ involvement, 15 multiple organ involvement. Fifty patients out of 59 with true positive PET/CT had raised tumor markers,either carcino-embryonic antigen (CEA) or CA 15-3 , while 2 patients with raised tumor markers showed negative PET/CT study(FN). Forty eight patients had normal serum level of tumor markers, nine of them showed positive PET/CT study. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT were 96.7, 89.7, 93.7,94.2 and 94% respectively. These parameters were 72.1, 82, 86.3, 65.3 and 76% for conventional imaging modalities.
Conclusion: PET-CT is a powerful diagnostic method in the restaging of breast cancer and detection of metastases in patients with raised serum tumor markers and/or negative or equivocal radiologic imaging modalities, however conventional imaging modalities with multiphase CT or MRI are more sensitive in detection of early small lesions in liver and lung.

DOI

10.21608/egyjnm.2013.5465

Keywords

conventional imaging modalities, 18F- FDG-PET/CT, tumor markers

Authors

First Name

jehan

Last Name

younis

MiddleName

ahmed

Affiliation

department of Oncology and Nuclear medicine, faculty of medicine, Cairo university, Cairo, Egypt

Email

jehan.nuc@hotmail.com

City

cario

Orcid

-

First Name

Hosna

Last Name

Moustafa

MiddleName

-

Affiliation

Oncology and Nuclear Medicine Department, Kasr Al-Aini Hospital, Cairo University, Egypt.

Email

drhosna1947@gmail.com

City

-

Orcid

-

First Name

Khalid

Last Name

Taalab

MiddleName

-

Affiliation

Nuclear Medicine Consultant in El-Galaa Hospital & Maadi Armed Forced Hospital.

Email

ktaalab@gmail.com

City

-

Orcid

-

Volume

7

Article Issue

7

Related Issue

947

Issue Date

2013-06-01

Receive Date

2018-02-21

Publish Date

2013-06-01

Page Start

30

Page End

38

Print ISSN

1687-4994

Online ISSN

2536-9113

Article File

EGYJNM_Volume 7_Issue 7_Pages 30-38.pdf

PDF . 214.5kB

Link

https://egyjnm.journals.ekb.eg/article_5465.html

Detail API

https://egyjnm.journals.ekb.eg/service?article_code=5465

Order

4

Type

Original Paper, Oncology

Type Code

380

Publication Type

Journal

Publication Title

Egyptian Journal Nuclear Medicine

Publication Link

https://egyjnm.journals.ekb.eg/

MainTitle

Role of 18F- FDG-PET/CT in Restaging of Breast Cancer Patients with High Tumour Markers and Equivocal Radiological Imaging

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Type

Article

Created At

22 Jan 2023