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5463

FDG-PET/CT in Early Assessment of Response to Therapy in Pediatric Hodgkin Lymphoma

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Last updated: 22 Jan 2023

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Abstract

Purpose of the study: was to estimate the value of early assessment of response in pediatric Hodgkin lymphoma (PHL) patients using FDG-PET/CT. Methods: prospective analysis of 195 patients presented in Children's Cancer Hospital, Egypt (CCHE) with pathologically proven untreated PHL, they underwent
18 F-fluorodeoxyglucose positron emission tomography (F-18 FDG PET/CT) early after 2 cycles of chemotherapy (PET 2).This chemotherapy regimen consists of concurrent treatment with Adriamycin, Bleomycin ,Vinblastine & Dacarbazine (ABVD). Analysis of PET 2 was done according to the Deauville score (5-point score) with cut-off 3-4 between Minimal Residual Uptake (MRU) and positive result. Results: Follow-up was done for mean period of 2.9 years (range, 0.6 to 5.2 years).Visual assessment of PET 2 was found to be significantly correlated with Overall Survival (OS) and Progression Free Survival (PFS) in advanced stages PHL (intermediate and high risk patients); the estimate for OS and PFS was 83.3% and 68.8 respectively in the PET-positive (PET +ve) group compared with 97.3% and 92.6|% respectively in the PET-negative (PET – ve) group (p-value <0.0001 and 0.0001).
Conclusion: Early assessment of FDGPET/CT after 2 cycles of ABVD in PHL shows potential value in prediction of OS and PFS in advanced stages (intermediate and high risk patients).

DOI

10.21608/egyjnm.2013.5463

Keywords

FDG-PET/CT, pediatric HL, prognosis

Authors

First Name

Shimaa

Last Name

Hussien

MiddleName

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Affiliation

Department of Nuclear Medicine and Radiation Oncology, faculty of medicine, Cairo University, Cairo, Egypt.

Email

shimos81@yahoo.com

City

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Orcid

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First Name

Hosna

Last Name

Moustafa

MiddleName

-

Affiliation

Oncology and Nuclear Medicine Department, Kasr Al-Aini Hospital, Cairo University, Egypt.

Email

drhosna1947@gmail.com

City

-

Orcid

-

Volume

7

Article Issue

7

Related Issue

947

Issue Date

2013-06-01

Receive Date

2018-02-21

Publish Date

2013-06-01

Page Start

6

Page End

17

Print ISSN

1687-4994

Online ISSN

2536-9113

Article File

EGYJNM_Volume 7_Issue 7_Pages 6-17.pdf

PDF . 353.0kB

Link

https://egyjnm.journals.ekb.eg/article_5463.html

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https://egyjnm.journals.ekb.eg/service?article_code=5463

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Type

Original Paper, Oncology

Type Code

380

Publication Type

Journal

Publication Title

Egyptian Journal Nuclear Medicine

Publication Link

https://egyjnm.journals.ekb.eg/

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Article

Created At

22 Jan 2023