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232192

Histological Study of Human Placenta in Preeclampsia and the Role of Decidual Natural Killer Cells and Macrophages in its Pathogenesis

Article

Last updated: 22 Jan 2023

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Abstract

Background: Preeclampsia (PE) is a hazardous pregnancy condition, if untreated can result in serious complications to the
mother and the fetus.
Aim: Investigating the histological changes of human placenta in PE and the involvement of natural killer (NK) cells and
macrophages in its pathogenesis.
Materials and Methods: Forty pregnant women were included; 20 were normal clinically and considered the control (group < br />I) and the other 20 were included in PE (group II). Blood samples were taken just before delivery to assess serum interleukins
(IL)-10 and -12 and transforming growth factor (TGF)-β1. Placental sections were stained with H&E, Mallory's trichrome and
immunohistochemically with Bcl-2, vascular endothelial growth factor (VEGF), CD56 and CD68. Then morphometric and
statistical studies were done.
Results: Group II (PE) showed significantly decreased IL-10 and significantly increased IL-12 and TGF-β1 compared to
group I. It also presented different histological alterations in placental sections mainly in the chorionic plates and villi. There
was significant increase in area percent of collagen fibers and VEGF, and in the number of syncytial knots, CD56 positive
decidual NK cells and CD68 positive decidual macrophages. But there was significant decrease in the area percent of Bcl-2
immunoexpression.
Conclusion: Preeclampsia is associated with marked inflammatory and immune responses, and decidual NK cells and
macrophages are highly imperative cells in its pathogenesis.

DOI

10.21608/jmh.2020.45496.1084

Keywords

Decidual macrophages, decidual natural killer cells, placenta, preeclampsia

Authors

First Name

Mira

Last Name

Youssef

MiddleName

-

Affiliation

Departments of Histology, Faculty of Medicine, Cairo University, Egypt

Email

mira_farouk@yahoo.com

City

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Orcid

-

First Name

Sahar

Last Name

Abo El Fadl

MiddleName

-

Affiliation

Departments of Histology, Faculty of Medicine, Cairo University, Egypt

Email

-

City

-

Orcid

-

First Name

Nada

Last Name

Abd El Wahab

MiddleName

-

Affiliation

Departments of Histology, Faculty of Medicine, Cairo University, Egypt

Email

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City

-

Orcid

-

First Name

Dalia

Last Name

Ismail

MiddleName

-

Affiliation

Departments of Histology, Faculty of Medicine, Cairo University, Egypt

Email

drdaliaibrahim@hotmail.com

City

-

Orcid

0000-0001-6514-1531

Volume

4

Article Issue

2

Related Issue

33281

Issue Date

2020-12-01

Receive Date

2020-10-07

Publish Date

2020-12-01

Page Start

176

Page End

188

Print ISSN

2536-9172

Online ISSN

2536-930X

Link

https://jmh.journals.ekb.eg/article_232192.html

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https://jmh.journals.ekb.eg/service?article_code=232192

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3

Type

Original Article

Type Code

332

Publication Type

Journal

Publication Title

Journal of Medical Histology

Publication Link

https://jmh.journals.ekb.eg/

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Article

Created At

22 Jan 2023