Background: Type 1 diabetes mellitus affects lungs due to poor glycemic control. Improvement in both lung function and
architecture in experimentally-induced lung injury that received exogenous AMSCs by different mechanisms was found.
Curcumin has a potent antioxidant and antifibrotic function.
Objective: The current study was designed to elucidate the possible ameliorative role of mesenchymal stem cells and curcumin
on the lung in experimentally induced type I diabetes by histological and immunohistochemical study.
Materials and Methods:Twenty six adult albino rats were divided into five groups: donor, control group, curcumin group and
adipose derived mesenchymal stem cell (AMSCs) group. Group II (diabetic group) received a single dose STZ 50 mg/kg/day,
group III received STZ and powdered diet supplemented with 0.05% curcumin, group IV received STZ and 1x106 of cultured
and labelled rat AMSCs. Lung sections were subjected to histological, morphometric, biochemical and statistical studies.
Results: Diabetes induced histological changes in lung in the form of inflammatory changes in bronchiole, a sig increase in
the thickness of interalveolar septa, thickness of the vessels wall, area % of collagen and count CD105+ve cells. Sig decrease
in antioxidant activity and sig increase in oxidant enzymes. Sig increase in L-hydroxyproline(L-hyp) level as well STAT and
SMAD genes. Administration of curcumin and AMSCs improved sig the previous changes.
Conclusion: Diabetes induced lung injuries in rats that was ameliorated by by curcumin, but AMSCs have more pronounced
effect than curcumin therapy.