This study was undertaken at the private Farm, Bani Mazar District, Minia governorate. during the two seasons of 2020 and 2021 to investigate the effect of irrigation water salinity, mineral and biofertilization [effective microorganisms (EM) and Azotobacter chroococcum bacteria (AC)] treatments, and, their interactions on the vegetative growth of bermudagrass (Cynodon dactylon, L.), grown in sandy soil. Our results indicated that the vegetative growth traits (covering density, plant height, as well as, fresh and dry weights of clipping) were increased with the low level of salinity (3000 and 6000 ppm), while, they were decreased with the high level of salinity (9000 ppm) comparing with control treatment, with significant differences in some cases, in the three cuts during both seasons. The mineral and biofertilization treatments significantly increased the previous parameters compared with the control treatment, except some treatments (EM or AC) in 2^nd and 3^rd cuts with the highest values which were obtained due to 100% mineral NPK followed by biofertilizer (EM + AC), without significant differences in some cases, in the three cuts during both seasons. The interaction treatments were significant for all vegetative growth traits in the three cuts during both seasons. The best interaction treatments that mitigate the adverse effects of salinity (9000 ppm) were 100% mineral NPK followed by biofertilizer (EM + AC)