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257685

The correlation between laparoscopic staging of endometriosis and nerve fiber density in euotopic endometrium: A prospective Observational Study

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Last updated: 22 Jan 2023

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Abstract

Objective: Recent studies proved higher density of small nerve fibers
in euotopic endometrium in endometriotic females which can be used
for diagnosis of endometriosis.This study investigate this finding in a
sample of Egyptian females and also asses if there is difference in the
density of small nerve fibers in euotopic endometrium in different stages
of endometriosis diagnosed by laparoscopy.
Patients and Methods: A prospective observational study comprised of
Ninety-seven endometrial biopsies taken from women who underwent
laparoscopy for infertility and/or pelvic pain. Fourty seven biopsies were
from non endometriotic women, mean -while fifty were from endometriotic
ones.These biopsies stained with immunohistochemical stain using protein
gene product 9.5 (PGP9.5) as amarker for nerve fibers.
Results: Nerve fiber density in euotopic endometrium was significantly
higher in endometriotic group than non-endometriotic group (9.70 ± 2.29
vs. 1.53 ± 0.78, p value 0.001).In the endometriotic group nerve fiber
density significantly differs in different laparoscopic stages (F15.611)
(p < 0.001).
Conclusions: Detection of nerve fiber density through endometrial biopsy
can be used as a semi-invasive method for diagnosis of endometriosis and
may be helpful for staging

DOI

10.21608/egyfs.2015.257685

Keywords

Keywords: endometriosis diagnosis, Immunohistochemistry, endometrial biopsy, nerve fibers

Authors

First Name

Abdelhady Zayed , Yasser Mesbah,

Last Name

Ahmed Badawy , Ahmed El-Zayadi

MiddleName

Osama Warda , Ahmed Ragab ,

Affiliation

Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt

Email

zayed_hady@yahoo.com

City

Mansoura

Orcid

-

Volume

19

Article Issue

2

Related Issue

36480

Issue Date

2015-06-01

Receive Date

2022-09-03

Publish Date

2015-06-01

Page Start

45

Page End

50

Print ISSN

1110-6352

Online ISSN

2536-9768

Article File

EGYFS_Volume 19_Issue 2_Pages 45-50.pdf

PDF . 2.0MB

Link

https://egyfs.journals.ekb.eg/article_257685.html

Detail API

https://egyfs.journals.ekb.eg/service?article_code=257685

Order

7

Type

Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility of Sterility

Publication Link

https://egyfs.journals.ekb.eg/

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Details

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Article

Created At

22 Jan 2023