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257490

Prednisolone in unexplained implantation failure: a randomized controlled clinical trial of efficacy

Article

Last updated: 03 Jan 2025

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Abstract

Objective: To evaluate of the effect of adding prednisolone to improve
the outcomes of intracytoplasmic sperm injection (ICSI) in women with
previous unexplained implantation failure.
Materials & Methods: This is a randomized controlled study performed
in Fertility Care Unit in Mansoura University Hospital and private fertility
care centers, Mansoura, Egypt. The study comprised of women undergoing
ICSI and has history of one or more implantation failure. All women were
randomly divided into two groups; the study group received prednisolone
in a dose of 20 mg/day starting from the day of oocyte retrieval while
the control group received no treatment. The primary outcome was clinical pregnancy rate and the secondary outcomes were implantation rate and
miscarriage rate.
Results: 108 women (53 in the study group and 55 in the control group)
subjected to final analysis. There was no significant difference between
the study and control groups as regard the clinical pregnancy rate (45.3%
vs 32.7%; P = 0.237), implantation rate (22.1% vs 15.2%; P = 0.145) and
miscarriage rate (33.3% vs 33.3%; P = 1.000).
Conclusion: Administration of prednisolone in the luteal phase to women
with previous unexplained implantation failure does not result in significant increase in clinical pregnancy or implantation rates.

DOI

10.21608/egyfs.2015.257490

Keywords

Key Words: ICSI, Implantation Failure, Prednisolone

Authors

First Name

Mohamed Sayed Abdelhafez,

Last Name

Waleed El-refaie

MiddleName

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Affiliation

Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt

Email

msabdelhafez@gmail.com

City

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Orcid

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Volume

19

Article Issue

1

Related Issue

36463

Issue Date

2015-01-01

Receive Date

2022-09-01

Publish Date

2015-01-01

Page Start

28

Page End

33

Print ISSN

1110-6352

Online ISSN

2536-9768

Article File

EGYFS_Volume 19_Issue 1_Pages 28-33.pdf

PDF . 2.0MB

Link

https://egyfs.journals.ekb.eg/article_257490.html

Detail API

https://egyfs.journals.ekb.eg/service?article_code=257490

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5

Type

Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility of Sterility

Publication Link

https://egyfs.journals.ekb.eg/

MainTitle

Prednisolone in unexplained implantation failure: a randomized controlled clinical trial of efficacy

Details

Type

Article

Created At

22 Jan 2023