Subjects
-Tags
-Abstract
Objective: To evaluate the role of nuclear vacuole ratio as determinant of
unexplained infertility and assessment of its risk factors.
Patients and method:This prospective comparative study included two
groups of infertile couples: group A included 20 couples with unexplained
infertility and group B included 20 couples with secondary infertility due
to female factor and normal semen analysis. MSOME was used for further
individual sperm retrieval. Vacuoles > 50% of nuclear area were considered large nuclear vacuoles (LNV).
Results:55% of males with unexplained infertility have spermatozoa with
LNV versus only 10% of males with secondary infertility. It was estimated
that odds ratio of presence of LNV among males with unexplained infertility is 11 (95% CI: 1.7 – 115.2). Older age, smoking habit and presence
of chronic disease are significant risk factors for presence of spermatozoa
with LNV with odd ratio 19.5, 26.7 and 30.3 respectively.
Conclusion:Spermatozoa with LNV are potential cause for infertility
among couples with unexplained infertility and further research is highly
recommended.
DOI
10.21608/egyfs.2013.257477
Keywords
Keywords: Infertility, MSOME, Nuclear vacuoles, Large nuclear vacuoles
Authors
First Name
Elham Hussein Madny,
MiddleName
Mohamed M farrag, Amro S khodir,
Affiliation
Department of Obstetrics
and Gynecology, Faculty of
Medicine, Suez Canal University
Email
-City
-Orcid
-Link
https://egyfs.journals.ekb.eg/article_257477.html
Detail API
https://egyfs.journals.ekb.eg/service?article_code=257477
Publication Title
The Egyptian Journal of Fertility of Sterility
Publication Link
https://egyfs.journals.ekb.eg/
MainTitle
SPERM NUCLEAR VACUOLES RATIO AS A DETERMINANT FOR UNEXPLAINED INFERTILITY AND ITS RISK FACTORS