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257474

COMBINED COENZYME Q10 AS AN ADJUVANT FOR OVULATION INDUCTION IN POLYCYSTIC OVARY SYNDROME

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Last updated: 03 Jan 2025

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Abstract

Objective: To evaluate the effect of combination of oral Coenzyme Q10
(CoQ10), with clomiphene citrate (CC) for ovulation induction in CC-resistant polycystic ovary syndrome (PCOS).
Patients and method:A prospective controlled randomized trial which
comprised of 110 infertile women with PCOS resistant to CC. Patients
were randomized to either combined CC/CoQ10 (51 patients, 82 cycles)
or CC 150 mg/day alone (50 patients, 71 cycles) for ovulation induction in
patients with CC-resistant PCOS. The main outcome measures were number of follicles, serum E2, serum P, endometrial thickness, and pregnancy
rate (PR) and miscarriage rate.
Results:Combination of CC and coenzyme Q10 significantly increased
both ovulation (p < 0.001) and pregnancy rates (p < 0.001) in women with
CC-resistant PCOS compared with CC only, (65.9% vs.15.5% and 39.2%
vs. 6%, respectively). No women reported side effects.
Conclusion:Combination of CoQ10-CC in the treatment of CC-resistant
PCOS patients improves the ovulation and pregnancy rates. It is an effective, safe option and should be considered before gonadotropin therapy or
laparoscopic ovarian drilling.

DOI

10.21608/egyfs.2013.257474

Keywords

Key Words: Coenzyme Q10, polycystic ovary syndrome, clomiphene-citrate resistance, Pregnancy

Authors

First Name

Abdelaziz A. Elrefaeey,

Last Name

Khaled R. Zalata

MiddleName

Anas M. Gama, Iman Yassein,

Affiliation

1Department of Obstetrics and Gynecology, 2Department of Pathology, Faculty of Medicine, Mansoura University, Egypt

Email

refaeeysat@yahoo.com

City

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Orcid

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Volume

17

Article Issue

2

Related Issue

36462

Issue Date

2013-06-01

Receive Date

2022-09-01

Publish Date

2013-06-01

Page Start

12

Page End

15

Print ISSN

1110-6352

Online ISSN

2536-9768

Article File

EGYFS_Volume 17_Issue 2_Pages 12-15.pdf

PDF . 1.4MB

Link

https://egyfs.journals.ekb.eg/article_257474.html

Detail API

https://egyfs.journals.ekb.eg/service?article_code=257474

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Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility of Sterility

Publication Link

https://egyfs.journals.ekb.eg/

MainTitle

COMBINED COENZYME Q10 AS AN ADJUVANT FOR OVULATION INDUCTION IN POLYCYSTIC OVARY SYNDROME

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Article

Created At

22 Jan 2023