Objective: Evaluate the impact of high number of retrieved oocytes on the outcome of ICSI cycles.   Material and methods: A retrospective study performed in Mansoura integrated fertil- ity center. We reviewed 1566 ICSI cycles and compared the patient, cycle features and cycle outcome of ICSI for high responders (> 15 retrieved oocytes corresponding to > 75th percentile) and normal responders (5- 15 oocytes between 25th and 75th percentile). Results: High responders were significantly younger and thinner than the normal respond- ers. The oocyte maturation was significantly lower in high responders. Fertilization rate, Implantation rate and the clinical pregnancy rate revealed significant differences being lower in high responders.   Conclusion: High oocyte yield is detrimental to ICSI outcome. It does not only affect the maturation of oocyte but also affects the fertilization, the implantation and the clinical pregnancy rate.