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257690

Letrozole in poor responders undergoing ICSI: an egyptian experience

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Last updated: 03 Jan 2025

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Abstract

Objective: to compare gonadotropine /antagonist protocol with and without Letrozole for
controlled ovarian hyperstimulation for poor responder cases undergoing ICSI.
Materials & Methods: A prospective randomized case control study performed in Mansoura Fertility Care unit, Mansoura University hospital. Controlled ovarian hyperstimulation using gonadotropins/antagonist protocol with (group A) and without Letrozole
(group B). The primary outcome is to measure duration of stimulation, total dose of gonDGRWURSLQVVHUXP(OHYHODQGHQGRPHWULDOWKLFNQHVVRQGD\RI+&*DGPLQLVWUDWLRQ7KH
number and degree of maturation of retrieved oocytes, fertilization rate and number and
grade of the developed embryos were evaluated. Secondary outcome includes ongoing
pregnancy and take home baby rates.
Results: Duration of stimulation was shorter in group A (10.2± 1.5 days) compared to
(11.5± 1.9days) in group B, total dose of gonadotropins was lower in group A (2602±433)
in contrast to (2752±515IU) in group B, endometrial thickness was thicker in group B
“PP FRPSDUHGWR “PP LQJURXS$EXWQRVLJQL¿FDQWGLIIHUHQFHZDVGHtected between the two groups apart from mean duration of stimulation.
Conclusions: Letrozole as an adjuvant to gonadotropins seems to reduce stimulation period and total gonadotropins units used.

DOI

10.21608/egyfs.2012.257690

Keywords

Key wards: Letrozole, poor responders, controlled ovarian hyperstimulation, ICSI Cycles

Authors

First Name

Mohamed Ibrahem,

Last Name

Mohamed Elnegeri

MiddleName

Hesham Shalan, Abd El Gawad Elmetwally,

Affiliation

Obstetrics and Gynecology. Mansoura University Hospital. Mansoura, Egypt

Email

drshalan@yahoo.com

City

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Orcid

-

Volume

16

Article Issue

2

Related Issue

36457

Issue Date

2012-06-01

Receive Date

2022-09-03

Publish Date

2012-06-01

Page Start

26

Page End

28

Print ISSN

1110-6352

Online ISSN

2536-9768

Article File

EGYFS_Volume 16_Issue 2_Pages 26-28.pdf

PDF . 1.2MB

Link

https://egyfs.journals.ekb.eg/article_257690.html

Detail API

https://egyfs.journals.ekb.eg/service?article_code=257690

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Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility of Sterility

Publication Link

https://egyfs.journals.ekb.eg/

MainTitle

Letrozole in poor responders undergoing ICSI: an egyptian experience

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Type

Article

Created At

22 Jan 2023