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clinical and biochemical parameters, ovulation and pregnancy rates in obese and non
obese patients with polycystic ovary syndrome.
Materials & Methods : A prospective comparative study in Minia University infertility
clinic comprised of 100 infertile women who were diagnosed as clomiphene citrate resistant polycystic ovary syndrome at the period startingIURP1RYHPEHU WR$XJXVW7KHSDWLHQWVZHUHGLYLGHGLQWRJURXSV *URXS 2 LQFOXGHGSDWLHQWVZLWK
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received metformin 850 mg tablet twice daily for 12 weeks. The primary outcomes were
the ovulation rate, the degree of menstrual regularity , the change of the patients‘ clinical
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Results :7KHUHZDVDVWDWLVWLFDOO\VLJQL¿FDQWLPSURYHPHQWDVUHJDUGVSUHDQGSRVWWUHDWPHQWFRQFHUQLQJUHJXODULW\RIWKHF\FOH S DFQH S DQG/+ )6+UDWLR
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post-treatment concerning regularity of the cycle (p=0.0001 & 0.0002) , acne (p=0,028
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DVUHJDUGKLUXVWLVPLQERWKJURXSV+RZHYHUWKHUHZHUHQRVWDWLVWLFDOO\VLJQL¿FDQWGLIferences between the two groups concerning the ovulation and pregnancy rates after
treatment.
Conclusions : Metformin alone may be an effective drug for restoration of menstrual irUHJXODULWLHV/+ )6+UDWLRWUHDWPHQWRIDFQHLQGXFLQJRYXODWLRQDQGLQFUHDVHSUHJQDQF\
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FRQWUROOHGVWXGLHVRQODUJHQXPEHURISDWLHQWVDUHUHTXLUHGWRFRPSDUHHI¿FDF\RIPHWformin in obese and non obese PCOS patients.