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257283

Can protein Z deficiency predict pregnancy outcome?

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Last updated: 03 Jan 2025

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Abstract

Objecive: The objective of this was to determine if preeclampsia (PE), intrauterine growth
restriction “IUGR"; or intra-uterine fetal death “IUFD" are associated with changes in
maternal plasma concentrations of protein Z.
Methods: This is a prospective case control study which comprised of 130 pregnant
women.Theyweredividedinto4groupd:Severepreeclampsiagroup(n=40),unexplained
IUGR group (n=25), Unexplained IUFD group (n=25) and 40 women with normal
pregnancy as a control group. Cross sectional maternal plasma protein Z concentrations
were measured by a sensitive and specific immunoassay.
Results: There was a statistical significant difference regarding protein Z between control
group and complicated pregnancies (p=0.047). Protein Z levels were significantly lower in
severe preeclamptic patients was than that of the other study groups p < 0.0001. However,
there was no significant difference in the maternal plasma protein Z concentration between
patients with unexplained IUGR or intrauterine fetal demise.
Conclusion: Preeclampsia is associated with significantly lower maternal median plasma
concentration of protein Z than normal pregnancy and also a high rate of protein Z
deficiency was observed in patients with IUGR and fetal demise.

DOI

10.21608/egyfs.2012.257283

Keywords

Keywords: preeclampsia, intrauterine growth restriction, fetal demise, protein Z dependent protease inhibitor (ZPI)

Authors

First Name

Maged Raghib,

Last Name

H Gouda

MiddleName

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Affiliation

Department of Obstetrics and Gynecology, Mansoura University Hospitals, Mansoura, Egypt.

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Volume

16

Article Issue

1

Related Issue

36443

Issue Date

2012-01-01

Receive Date

2022-08-31

Publish Date

2012-01-01

Page Start

23

Page End

26

Print ISSN

1110-6352

Online ISSN

2536-9768

Article File

EGYFS_Volume 16_Issue 1_Pages 23-26.pdf

PDF . 1.3MB

Link

https://egyfs.journals.ekb.eg/article_257283.html

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https://egyfs.journals.ekb.eg/service?article_code=257283

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Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility of Sterility

Publication Link

https://egyfs.journals.ekb.eg/

MainTitle

Can protein Z deficiency predict pregnancy outcome?

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Article

Created At

22 Jan 2023