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257275

Uterine Receptivity Assessed By Three Dimensional Ultrasound and Power Doppler in Women with Polycystic Ovary Syndrome Treated By Clomiphene Citrate Alone or Combined To Metformin

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Last updated: 03 Jan 2025

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Abstract

Objective: A prospective randomized single blinded study was carried out to examine
whether metformin when combined with clomiphene citrate (CC) had an added effect, if
any, on uterine receptivity.
Patients and Methods: Seventy seven egyptian women with polycystic ovary syndrome
(PCOS) aging between 20-35 years were randomized to 2 groups received either 100 mg
cc for 5 days alone, or with metformin 850mg bid throughout menstrual cycle. Three
dimensional (3D) ultrasound with power Doppler examination was done on day 2 after
human chorionic gonadotropin (hCG) injection for both groups and; endometrial volume,
vascularization index (VI), flow index (FI), and vascularization flow index (VFI) of endometrial and subendometrial regions were measured.
Results: Patients taking metformin, and those destined to be pregnant had significantly
lower VI/FI/VFI in endometrial region. Corresponding decreases of values in subendometrial region were insignificant. Serum estradiol (E2) levels on day of hCG injection
were significantly lower in cycles, where metformin was added.
Conclusion: Metformin had significantly lowered VI/FI/VFI in early luteal phase in
PCOS affected women.

DOI

10.21608/egyfs.2011.257275

Keywords

Key Words: Uterine Receptivity, three dimensional ultrasound, power doppler, polycystic ovary syndrome, Clomiphene citrate, Metformin

Authors

First Name

Hanan A. Ghali,

Last Name

Amal A. Zidan

MiddleName

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Affiliation

1 Depatment of Obstetrics & Gynecology, Zagazig University, 2 Department of Clinical Pathology, Zagazig University

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Volume

15

Article Issue

2

Related Issue

36441

Issue Date

2011-12-01

Receive Date

2022-08-31

Publish Date

2011-12-01

Page Start

38

Page End

42

Print ISSN

1110-6352

Online ISSN

2536-9768

Article File

EGYFS_Volume 15_Issue 2_Pages 38-42.pdf

PDF . 2.1MB

Link

https://egyfs.journals.ekb.eg/article_257275.html

Detail API

https://egyfs.journals.ekb.eg/service?article_code=257275

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Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility of Sterility

Publication Link

https://egyfs.journals.ekb.eg/

MainTitle

Uterine Receptivity Assessed By Three Dimensional Ultrasound and Power Doppler in Women with Polycystic Ovary Syndrome Treated By Clomiphene Citrate Alone or Combined To Metformin

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Article

Created At

22 Jan 2023