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257273

Aromastase Inhibitor Therapy For Symptomatic Uterine Leimyomata In Premenopausal Women

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Last updated: 03 Jan 2025

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Abstract

Objective: To examine the effect of letrozole on symptomatic leiomyomata.
Patients and Methods: In a prospective, intervention study , forty six premenopausal
women with fifty two leiomyomata were invited to take 5 mg letrozole daily for 3
treatment cycles of 28 days each. Leiomyoma, uterine and ovarian volumes, endometrial
thickness, gonadotrophins, and the scores of menstrual pictograms and Uterine Fibroid
Symptom and Health Related Quality of Life (UFS – HRQoL) were recorded at the start
and conclusion of this study.
Results: Letrozole resulted in 53.29% mean reduction in original leiomyomata volumes
(P < 0.01) without significant reduction in myoma free uterine tissue. Estradiol levels
dropped significantly from baseline levels (64.32 + 16.77) (mean + SD) to (40.83 +
12.032) pg/ml (p < 0.001) at the end of this study.
Conclusion: Adding to its significant shrinkage of leiomyomta, letrozole improved
leiomyoma related symptomology, quality of life
and menstrual pattern significantly.

DOI

10.21608/egyfs.2011.257273

Authors

First Name

Hanan A.A

Last Name

Ghal

MiddleName

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Affiliation

Department of Obstetrics and Gynecology, Faculty of medicine, Zagazig University

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Orcid

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Volume

15

Article Issue

2

Related Issue

36441

Issue Date

2011-12-01

Receive Date

2022-08-31

Publish Date

2011-12-01

Page Start

29

Page End

33

Print ISSN

1110-6352

Online ISSN

2536-9768

Article File

EGYFS_Volume 15_Issue 2_Pages 29-33.pdf

PDF . 1.9MB

Link

https://egyfs.journals.ekb.eg/article_257273.html

Detail API

https://egyfs.journals.ekb.eg/service?article_code=257273

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Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility of Sterility

Publication Link

https://egyfs.journals.ekb.eg/

MainTitle

Aromastase Inhibitor Therapy For Symptomatic Uterine Leimyomata In Premenopausal Women

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Article

Created At

22 Jan 2023