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170462

Coasting Versus GnRH Antagonist administration in Patients at High Risk of Ovarian Hyper stimulation Syndrome and its impact on the ICSI Outcome

Article

Last updated: 03 Jan 2025

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Abstract

Objectives: study the value of GnRH antagonist administration as an alternative protocol to coasting in preventing
severe OHSS in cases of long agonist ovarian stimulation protocol and its impact on embryos quality &positive
pregnancy in women undergoing ICSI.
Study design: A prospective randomized control trial is
done at the assisted Reproduction unit, Al-Azhar university, Egypt to compare Coasting group (n = 150) and GnRH
antagonist group (n = 150) in patients detected to be at
risk of OHSS during the process OHSS in cases of long
agonist ovarian stimulation protocol before ICSI. The primary outcome was high quality embryos, the secondary
outcome was days of intervention, number of oocytes,
pregnancy outcome, number of cryopreserved embryos
and incidence of severe OHSS.
Results: There were statistical significant deference between quality embryos (2.3±1.2 versus 1.6±0.7; P value = 0.001) and more oocytes number (8.2±3.1) versus
(6.7±3.2; P value = 0.01) in Antagonist group as compared with coasting group. There were more number of
coasting days than with antagonist administration days
(2.9±1.4 versus 2.2±1.1; P value = 0.001).
Conclusion: GnRH antagonist was superior to coasting in
producing higher numbers of mature oocytes, high quality embryos and reducing the number of days till the HCG
injection. There was no statistical significant difference in
chemical pregnancy rate between two groups. No early
or late OHSS developed in either group.

DOI

10.21608/egyfs.2021.170462

Authors

First Name

Eman

Last Name

Hassan

MiddleName

Anwar

Affiliation

International Islamic Centre for Population Studies and Researches (IICPR) Al-Azhar University,

Email

emanembryology@gmail.com

City

-

Orcid

-

Volume

25

Article Issue

2

Related Issue

24805

Issue Date

2021-05-01

Receive Date

2021-05-17

Publish Date

2021-05-01

Page Start

19

Page End

27

Print ISSN

1110-6352

Online ISSN

2536-9768

Article File

EGYFS_Volume 25_Issue 2_Pages 19-27.pdf

PDF . 2.5MB

Link

https://egyfs.journals.ekb.eg/article_170462.html

Detail API

https://egyfs.journals.ekb.eg/service?article_code=170462

Order

3

Type

Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility of Sterility

Publication Link

https://egyfs.journals.ekb.eg/

MainTitle

Coasting Versus GnRH Antagonist administration in Patients at High Risk of Ovarian Hyper stimulation Syndrome and its impact on the ICSI Outcome

Details

Type

Article

Created At

22 Jan 2023