Background and aim: Ghrelin is a 28 amino acid peplide, which is primarily produced by the stomach. Ghrclin i.s a strong sccrelagogue of growth hormone (GH).The polycyslic ovary syndrome (PCOS) is Iradilionaliy characterized by chronic anovulalion, funclional hypcrandrogenism. Obesity of the central type and Insulin Resistance (IR) arc highly associated with the syndrome, predisposing women with PCOS to the development of glucose intolerance and. ultimately, type 2 diabetes mcllitus. In the current study, we investigated fasting plasma ghrelin levels in a group of patients with PCOS, with and without type 2 DM, and compared with an age matched control group. Results: Fasting plasma ghrclin was significantly lower in PCOS patients than in control groups.
Conclusion: Fasting plasma ghrelin levels were significantly lower in PCOS groups as compared to the control group, Decreased plasma ghrclin levels correlated significantly with Insulin resistance in the patients groups.