Objectives : To test if Corticosleroids (mcthylprcdniosolonc) reduces and prevents OHSS in women undergoing
IVF-ICSI cycles.
Design : Prospective, randomized study.
Setting : Shalby hospital for women and Elmadina IVF-ICSI center.
Patients : 67 women undergoing IVF-ICSI from May 2006 to April 2007.
Intervention : Corticostcroid (Mcthylprcdinsolonc), was given at the day of oocyle recovery till the day of pregnancy
test then the dose was tapered.
Main Outcome Measure(s) : Occurrence of OHSS and pregnancy.
Results : A significantly lower proportion of methylprcdnisolone recipients than untreated participants developed
OHSS (20% vs. 43%). Treatment recipients had more oocytcs retrieved and moc embryos fertilized than did untreated
participants.
Conclusions : Given the corticostcroid (methylprcdnisolone) is a well established and safe medication. This study
provides evidence that the use of methylprcdnisolone in the prevention of OHSS in women undergoing assisted
reproduction, is successful and without affection of the pregnancy rate.