Objective: The aim of the present study is to synthesize novel 2-furanones due to their biological activities and also their ability to be converted to several biologically active heterocyclic and non-heterocyclic compounds. Methods: Two novel 2-furanone derivatives were synthesized and used to prepare fourteen heterocyclic and non-heterocyclic compounds. Structures of all the newly synthesized compounds were confirmed by elemental and spectral analysis including Mass, IR and ¹H-NMR spectroscopy. Evaluation of antiviral activity of selected examples of the obtained compounds was performed using two gastroenteric viruses: adenovirus and rotavirus. Results: Two pyridazinone derivatives namely; 3-(3,4-Dichlorophenyl)-5-[(2-methoxypheny)l-methyl]-1H-pyridazin-6-one (7a) and 3-(3,4-Dichlorophenyl)-5-[(4-fluropheny)l-methyl]-1H-pyridazin-6-one (7b) showed high activities against rotavirus. Conclusions: Compounds 7a and 7b can be considered as promising anti-rotaviral agents needing further investigations and clinical studies.