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118763

Determination of Ivabradine by Linear Sweep, Square Wave and Differential Pulse Voltammetric Methods Using Platinum Electrode in Pharmaceutical Preparation

Article

Last updated: 03 Jan 2025

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Tags

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Abstract

Objectives: In this study, simple, fast and reliable cyclic voltammetry (CV), linear sweep voltammetry (LSV), square wave voltammetry (SWV) and differential pulse voltammetry (DPV) methods were developed and validated for determination of ivabradine in pharmaceutical preparations. Methods: The proposed methods were based on electrochemical oxidation of ivabradine at platinum electrode in acetonitrile solution containing 0.1 M LiCIO4.The well-defined oxidation peak was observed at 1.34 V.  Results: The calibration curves were linear for ivabradine at the concentration range of 5-40 µg/mL for LSV, SWV and DPV methods, respectively. Intra- and inter-day precision values for ivabradine were less than 3.12, and accuracy (relative error) was better than 4.78%. The limits of detection values ranged from 1.20 to 1.60 µg/mL and quantification from 3.60 to 4.80 µg/mL. The mean recovery of ivabradine was 99.9% for pharmaceutical preparation. No interference was found from tablet excipients at the selected assay conditions. Conclusion: Developed methods in this study are accurate, precise and can be easily applied to Coralan tablet as pharmaceutical preparation.

DOI

10.21608/aprh.2020.30205.1107

Keywords

Ivabradine, Tablet, validation, Voltammetry

Authors

First Name

Bilal

Last Name

Yilmaz

MiddleName

-

Affiliation

Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey.

Email

yilmazb@atauni.edu.tr

City

Erzurum

Orcid

0000-0002-8574-7570

First Name

Bilge

Last Name

Akcay

MiddleName

-

Affiliation

Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey.

Email

ezgin20@hotmail.com

City

Erzurum

Orcid

-

Volume

4

Article Issue

4

Related Issue

18058

Issue Date

2020-10-01

Receive Date

2020-05-14

Publish Date

2020-10-01

Page Start

139

Page End

146

Print ISSN

2357-0547

Online ISSN

2357-0539

Link

https://aprh.journals.ekb.eg/article_118763.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=118763

Order

2

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

MainTitle

Determination of Ivabradine by Linear Sweep, Square Wave and Differential Pulse Voltammetric Methods Using Platinum Electrode in Pharmaceutical Preparation

Details

Type

Article

Created At

22 Jan 2023