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120578

Synthesis, Characterization and Anticancer Activity of Some Benzothiazole and Thiazole Derivatives

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Last updated: 03 Jan 2025

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Abstract

Objective: This study aimed synthesis of benzothiazole and thiazole derivatives due to the importance of these heterocycles as anticancer. Method: Novel benzothiazole and thiazole derivatives 2-40 were synthesized through different chemical reactions. Results: Structures of these compounds were confirmed by spectral and elemental analyses. The obtained compounds were evaluated for their in vitro antitumor activity against 60 human cancer cell lines by the National Cancer Institute (NCI). Conclusion: Twelve compounds 4, 6, 10, 12, 13, 16, 18, 20, 21, 25, 28b and 40 wereselected by NCI for evaluation and have anticancer activity.

DOI

10.21608/aprh.2020.27931.1104

Keywords

Anticancer, Benzothiazole, thiazole

Authors

First Name

Aisha

Last Name

Hassan

MiddleName

Y.

Affiliation

Department of Chemistry, Faculty of Science(Girls), Al-Azhar University, Nasr City, Cairo, Egypt.

Email

helali_aisha@yahoo.com

City

-

Orcid

-

First Name

Marwa

Last Name

Sarg

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.

Email

m.t.sarg@hotmail.com

City

-

Orcid

-

First Name

Ebtehal

Last Name

Husseiny

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.

Email

ebtehal.ouf@azhar.edu.eg

City

-

Orcid

-

Volume

4

Article Issue

4

Related Issue

18058

Issue Date

2020-10-01

Receive Date

2020-04-14

Publish Date

2020-10-01

Page Start

119

Page End

138

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 4_Issue 4_Pages 119-138.pdf

PDF . 1.0MB

Link

https://aprh.journals.ekb.eg/article_120578.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=120578

Order

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Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

MainTitle

Synthesis, Characterization and Anticancer Activity of Some Benzothiazole and Thiazole Derivatives

Details

Type

Article

Created At

22 Jan 2023