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Application of PVC Membrane and Modified Carbon Nanotubes Paste as Electrochemical Sensors for Potentiometric Determination of Loperamide Hydrochloride

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Last updated: 22 Jan 2023

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Abstract

Objectives: The main purpose of this work is to design a simple, sensitive, accurate and precise potentiometric membrane ion selective electrodes for selective determination of loperamide hydrochloride in bulk powder and in pharmaceutical preparation. Methods: Electrochemical behavior of loperamide hydrochloride were investigated using PVC membrane and modified carbon nanotubes paste sensors. The linearity of this developed method was established in the concentration range of 10-5 - 10-2 M and10-6 - 10-2 M shows a Nernstian slope of 57.38 mV and  58.74 mV for  PVC  and  Carbon paste sensor,  respectively. Results: Validation parameters such as specificity, linearity, accuracy, precision, stability, limit of detection were found to be within the acceptance limit as studied according  to  IUPAC recommendation data. Conclusion: Both sensors are successfully applied for potentiometric determination of loperamide hydrochloride in its pure form and pharmaceutical formulations.

DOI

10.21608/aprh.2020.24021.1099

Keywords

Ion selective electrodes, Loperamide hydrochloride, Modified carbon nanotubes paste sensor, PVC membrane sensor

Authors

First Name

Fathy

Last Name

Salama

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.

Email

fathysalama77@gmail.com

City

-

Orcid

-

First Name

Nasr

Last Name

El abasawy

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.

Email

nasrelabasawy@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

El-Olemy

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.

Email

ahmed_olemy2000@yahoo.com

City

Nasr City

Orcid

-

First Name

Mohamed

Last Name

Hasan

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.

Email

mohamedabdallah_87@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Kamel

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.

Email

kimo4army@gmail.com

City

Cairo

Orcid

-

Volume

4

Article Issue

2

Related Issue

12938

Issue Date

2020-04-01

Receive Date

2020-02-14

Publish Date

2020-04-01

Page Start

46

Page End

55

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 4_Issue 2_Pages 46-55.pdf

PDF . 548.6kB

Link

https://aprh.journals.ekb.eg/article_80262.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=80262

Order

2

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023