There is growing evidence supports the regulatory role of the immune system in neuronal function and mental health. Many studies have demonstrated the impact of the immune system in neurodegenerative disorders. There are beneficial therapeutic effects of targeting the immune system in the management of these disorders. However, there are gaps in the available knowledge and many steps are needed to move forward. Sensory contact model (SCM) is an experimental social behavior model which allows the formation of different psychopathological conditions which are originated between male mice by the repeated agonistic interactions; resemble those in human. SCM has been developed to investigate aggression and submission behaviors. It gives the chance to study the pharmacological actions of novel psychoactive drugs. The current study aims to review the possible relations between the immune system and social behavior; using the SCM as an experimental model of aggression and depression. To encourage the production of novel psychoactive drugs target the immune system and inflammatory pathways.