Objective: This study aimed to the synthesis fused pyridine due to the importance of these heterocycles both from chemical and biological points of view. Method: Pyridine derivatives 1a,b and 2a,b have been utilized for the synthesis of various fused pyridine through different chemical reactions to yield thieno [4,5-c]pyridine 6a,b,7a,b,8a,b, pyrido [2ꞌ,3ꞌ,2,3]thieno[4,5-d] pyrimidine 9a,b, 2,2ꞌ-bis-(3-cyano-4,6-diarylpyridyl)disulfide 10a,b,pyrido[4,5-b] pyrimidine 12a,b, [1,2,4]Triazolo[4,5-a]pyridine 13a,b,tetrazolo[4,5-a] pyridine 14a,b, bis(4,6-diaryl-3-cyanopyridine-2-yl)sulfide 15a,b, pyrido[2,3-b] Pyridine 16a,b, 17a,b, 18a,band thieno[2,3-b]-1,8-  naphthyridine 19a,b,20a,bderivatives. Pyrido[2,3-d] pyrimidinone derivatives 21a,b were used as starting material for synthesis thiazolo[3,2-a]pyrido[2,3-d] Pyrimidine 23a,b, 24b, 25b, 26a, 29a, thiazin[2,3-a]pyrido[2,3-d] pyrimidinone  28a,b and isoxazolo[5ꞌ,4ꞌ,4,5]thiazolo[3,2-a]pyrido[2,3-d] pyrimidinone derivatives 27a.The structures of the synthesized compounds were confirmed by IR,¹H and¹³C NMR, elemental analysis and mass spectra data. Conclusion: All structures of synthesized compounds agree with spectral data and elemental analysis.