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23581

Structural Characterization of Polyphenolics in <i>Livistona chinensis</i> Using HPLC-PDA-MS

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Last updated: 22 Jan 2023

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Abstract

Objectives: This study focused on the identification and characterization of secondary metabolites tentatively from aqueous ethanolic leaf extract of Livistona chinensisby HPLC-PDA-ESI-MS/MS and evaluation of its cytotoxic activity. Methods: The aqueous ethanolic extract was analyzed by high performance liquid chromatography (HPLC) coupled to photodiode array detection of mass spectroscopy (PDA-MS/MS), to detect the secondary metabolites in L. chinensis leaves extract. It was also estimated for its cytotoxicity againsthuman prostate carcinoma (PC3) and hepatocellular liver carcinoma (HepG2) cancer cell lines using SRB (3-(4, 5-dimethyl thiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. Results: Forty-two secondary metabolites were tentatively identified; the most major compounds were C-glycoside derivatives of apigenin, luteolin and tricin together with phenolic acids. The 70% alcoholic extract of L. chinensis leaves exhibit more antitumor activity against PC3than against HepG2. Conclusion:L. chinensis is a privileged source of C-flavonoids that revealed the efficiency of HPLC-MS metabolomics in natural products drug discovery.

DOI

10.21608/aprh.2018.6527.1072

Keywords

antitumor, HPLC, Livistona chinensis, Mass Spectroscopy, Phenolics

Authors

First Name

Rania

Last Name

Ahmed

MiddleName

-

Affiliation

Chemistry of Natural compounds Department, National Research Centre, El-Bohouth Street, Dokki, 12622, Giza, Egypt

Email

rfawzi@hotmail.com

City

-

Orcid

0000-0002-7068-7229

First Name

Ezz

Last Name

Elkhrisy

MiddleName

-

Affiliation

Chemistry of Natural compounds Department, National Research Centre, El-Bohouth Street, Dokki, 12622, Giza, Egypt

Email

ezzeldin083@gmail.com

City

-

Orcid

-

First Name

Walaa

Last Name

EL-kashak

MiddleName

Abdel Hameid

Affiliation

Department of Chemistry of Natural Compounds, National Research Centre, 33 El Bohouth St., Dokki, Giza, Egypt, P.O. 12622

Email

yossefashraf@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

El Raey

MiddleName

-

Affiliation

Chemistry of Natural compounds Department, National Research Centre, El-Bohouth Street, Dokki, 12622, Giza, Egypt

Email

elraiy@gmail.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Nassar

MiddleName

-

Affiliation

Chemistry of Natural compounds Department, National Research Centre, El-Bohouth Street, Dokki, 12622, Giza, Egypt

Email

mnassar_eg@yahoo.com

City

-

Orcid

-

First Name

El-Sayed

Last Name

Aboutabl

MiddleName

A.

Affiliation

Department of Pharmacognosy and Medicinal plants, Faculty of Pharmacy, Cairo Univeristy, Kasr-el Aini street, 11562, Cairo, Egypt

Email

mshanan@hotmail.com

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-

Orcid

-

Volume

3

Article Issue

1

Related Issue

4745

Issue Date

2019-01-01

Receive Date

2018-12-05

Publish Date

2019-01-01

Page Start

23

Page End

29

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 3_Issue 1_Pages 23-29.pdf

PDF . 348.0kB

Link

https://aprh.journals.ekb.eg/article_23581.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=23581

Order

3

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023