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16647

Acrylamide Moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide Derivatives

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Last updated: 22 Jan 2023

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Abstract

Acrylamide moiety is a pronounced Michael acceptor that has drawn much interest in a wide array of drugs designed for various therapeutic purposes. Herein we outline different synthetic pathways, scientific bases for its chemical reactivity and how it is functionalized for design of new therapeutic entities, in addition to a brief insight into spectrum of reported biological activities of acrylamide containing compounds up to date.

DOI

10.21608/aprh.2018.2839.1049

Keywords

acrylamide, antitumor, Covalent inhibitors, Kinase inhibitors, Michael acceptor

Authors

First Name

Hossam

Last Name

Elgiushy

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan 11795, Cairo, Egypt.

Email

hussamelgiushy@hotmail.com

City

nasr city cairo

Orcid

-

First Name

Sherif

Last Name

Hammad

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan 11795, Cairo, Egypt.

Email

sherifhammad2010@hotmail.com

City

cairo

Orcid

-

First Name

Ashraf

Last Name

Hassan

MiddleName

Sayed

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt

Email

ashraf_salmoon@yahoo.com

City

cairo

Orcid

0000-0002-4771-716X

First Name

Nageh

Last Name

Aboutaleb

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan 11795, Cairo, Egypt.

Email

dr.nagehabotaleb@yahoo.com

City

cairo

Orcid

-

First Name

khaled

Last Name

Abouzid

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University,Abbassia 11566 Cairo , Egypt

Email

khaled.abouzid@pharm.asu.edu.eg

City

cairo

Orcid

-

Volume

2

Article Issue

4

Related Issue

3784

Issue Date

2018-10-01

Receive Date

2018-02-05

Publish Date

2018-10-01

Page Start

221

Page End

237

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 2_Issue 4_Pages 221-237.pdf

PDF . 1.0MB

Link

https://aprh.journals.ekb.eg/article_16647.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=16647

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Type

Review Article

Type Code

358

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023