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Simultaneous Spectrophotometric Determination of Sacubitril and Valsartan in their Recently Approved Pharmaceutical Preparation

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Last updated: 22 Jan 2023

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Abstract

Three different spectrophotometric methods have been applied for simultaneous determination of sacubitril and valsartan. The developed methods are bivariate method, classical least square and principal component regression. The bivariate method is based on simple mathematic algorithm using two optimum wavelengths for the analysis of the mixture. On the other hand, two multivariate methods considering all the variables at the same time have been used to improve the quality of spectral analysis of the mixture. The proposed methods have been successfully applied for the determination of the two drugs in Entresto® tablets. Statistical comparisons between the obtained results and those obtained by the reported method have been performed showing no significant differences by applying t-test and F-test.

DOI

10.21608/aprh.2018.5825

Authors

First Name

Khalid

Last Name

Attia

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

dr.khalid64@yahoo.com

City

-

Orcid

-

First Name

Mohammed

Last Name

Nassar

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

mw-nassar@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

El-Olemy

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

ahmed_olemy2000@outlook.com

City

-

Orcid

-

First Name

Sherif

Last Name

Ramzy

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

ssherif14@yahoo.com

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

1044

Issue Date

2018-04-01

Receive Date

2017-11-28

Publish Date

2018-04-01

Page Start

133

Page End

141

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 2_Issue 2_Pages 133-141.pdf

PDF . 770.1kB

Link

https://aprh.journals.ekb.eg/article_5825.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=5825

Order

7

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023