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5826

Conductometric Titration for Determination of Trazodone Hydrochloride and Solubility Products of its Ion-Associated Complex Species

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Last updated: 22 Jan 2023

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Abstract

Objective: Conductometric determination of trazodone hydrochloride, with two precipitating reagents; Ammonium Reineckate and sodium tetraphenylborate has been investigated.Methods: The formed ion-associates were studied conductomterically for the determination of solubility products and other functions associated with the process of precipitating trazodone hydrochloride were determined. Moreover, two new maneuvers towards equivalence point detection were carried out. In this study, data processing was performed using numerical derivatization (second derivative) and Boltzmann algorithm. Results: Although, the described procedures allowed the determination of trazodone hydrochloride within the range of 2-14 mg using both reagents has less sensitivity other than reported method but has more advantages in simplicity, low cost , relatively short analysis time and direct analysis with good recoveries between 100.01% and 100.07% with relative standard deviation less than 2%. Conclusion: These methods were validated and successfully applied for the determination of trazodone hydrochloride in Trittico® tablets. The obtained results were statistically compared with those of the official method by applying t-test and F-value at 95% confidence level and no significant difference was observed regarding accuracy and precision.

DOI

10.21608/aprh.2018.5826

Keywords

Boltzmann sigmoid method, Conductometric, Numerical derivatization, Trazodone hydrochloride

Authors

First Name

Fathy

Last Name

Salama

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

fathysalama77@gmail.com

City

-

Orcid

-

First Name

Khalid

Last Name

Attia

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

dr.khalid64@yahoo.com

City

-

Orcid

-

First Name

Ragab

Last Name

Said

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

ragabmsaid@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

El-Olemy

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

ahmed_olemy2000@outlook.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdel-raoof

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

ahmedmeetyazeed79@yahoo.com

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

1044

Issue Date

2018-04-01

Receive Date

2017-11-13

Publish Date

2018-04-01

Page Start

113

Page End

122

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 2_Issue 2_Pages 113-122.pdf

PDF . 548.7kB

Link

https://aprh.journals.ekb.eg/article_5826.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=5826

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Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023