Beta
ManageSearchChatDiscover
5827

First Derivative Synchronous Spectrofluorimetric Determination of Cyproheptadine Hydrochloride in Presence of its Oxidative Degradation Product at Critical Micelle Concentration

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Simple and sensitive first derivative synchronous spectrofluorimetric method was developed for the determination of cyproheptadine hydrochloride in presence of its oxidative degradation product. The method was based on measuring the synchronous fluorescence of the drug in water at Δλ of 120 nm in the presence of a sodium dodecyl sulphate as a micellar system. The peak amplitude of the first derivative spectra was measured at 418 nm for the drug. The different experimental parameters affecting the synchronous fluorescence intensity of CYP were studied and optimized. The peak amplitude–concentration plot was rectilinear over the range of 0.1–1.6 µ gmL−1. The limit of detection (LOD) was 0.02 and quantification limit (LOQ) was 0.06 µgmL−1. The proposed method was successfully applied to commercial tablets. Statistical comparison of the results with those of the official method revealed good agreement and proved that there was no significant difference in the accuracy and precision of the two methods.

DOI

10.21608/aprh.2018.5827

Keywords

Cyproheptadine Hydrochloride, First derivative synchronous spectrofluorimetry, Micellar medium

Authors

First Name

Fathy

Last Name

Salama

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

fathysalama77@gmail.com

City

-

Orcid

-

First Name

Khalid

Last Name

Attia

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

dr.khalid64@yahoo.com

City

-

Orcid

-

First Name

Ragab

Last Name

Said

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

ragabmsaid@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

El-Olemy

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

ahmed_olemy2000@outlook.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdel-raoof

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

ahmedmeetyazeed79@yahoo.com

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

1044

Issue Date

2018-04-01

Receive Date

2017-11-12

Publish Date

2018-04-01

Page Start

104

Page End

112

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 2_Issue 2_Pages 104-112.pdf

PDF . 751.4kB

Link

https://aprh.journals.ekb.eg/article_5827.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=5827

Order

4

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023