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5828

Formulation and Characterization of Cubosomes Containing REB for Improvement of Oral Absorption of the Drug in Human Volunteers

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Last updated: 22 Jan 2023

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Abstract

Objectives: To prepare rebamipide (REB) -loaded cubosomal nanoparticles to improve the oral bioavailability of the drug in human volunteers. Methodology: The poorly water soluble drug REB was incorporated into cubosomal nanoparticles by solvent dilution method. The prepared REB-loaded cubosomes were in vitro characterized for particle size, polydispersity index (PDI), zeta potential, drug crystallinity and in vitro drug release. In vivo absorption of REB-loaded cubosomes was compared with drug powder and commercially available tablets Mucosta® (Egypt Otsuka Pharmaceutical Company) in healthy human volunteers. Results: In vitro, REB-loaded cubosomes entrapped about 82.44 % drug and revealed nanometer-size ranged from 303.1 ± 4.9 to 444.9 ± 6 nm. In vitro REB release from cubosomes exhibited a phase of rapid and high release of the drug during the first hour followed by a slower and complete drug release over a period of 3 hrs. The results of bioavailability study in healthy human volunteers showed that cubosomes significantly improved the rate and extent of REB absorption. The mean relative bioavailability of the REB loaded cubosomes compared to the drug powder and commercially available tablets (Mucosta®) was 191.23 ± 1.24 % and 166.29 ± 1.14 % respectively. Conclusion: The prepared cubosomes significantly improved the In-vivo absorption of REB in comparison with drug powder and commercially available tablets (Mucosta®).

DOI

10.21608/aprh.2018.5828

Keywords

Absorption, bioavailability, Cubosomes, rebamipide

Authors

First Name

Fahima

Last Name

Hashem

MiddleName

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Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo 11790, Egypt

Email

fahima20012000@yahoo.co.uk

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Orcid

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First Name

Mohamed

Last Name

Nasr

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo 11790, Egypt

Email

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City

-

Orcid

-

First Name

Mohamed

Last Name

Youssif

MiddleName

-

Affiliation

Egyptian Drug Authority, Ministry of Health, Cairo, Egypt

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Orcid

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Volume

2

Article Issue

2

Related Issue

1044

Issue Date

2018-04-01

Receive Date

2017-12-31

Publish Date

2018-04-01

Page Start

95

Page End

103

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 2_Issue 2_Pages 95-103.pdf

PDF . 510.7kB

Link

https://aprh.journals.ekb.eg/article_5828.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=5828

Order

3

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023