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5824

UV and First Derivative Spectrophotometric Methods for the Estimation of Atorvastatin in Pharmaceutical Preparations

Article

Last updated: 22 Jan 2023

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Abstract

Objective: In this study, new, rapid UV spectrophotometry (UV) and first-order derivative spectrophotometry (1D) methods were developed for the determination of atorvastatin in pure and tablets. Methods: The solvent system and wavelength of detection were optimized in order to maximize the sensitivity of the proposed methods. Parameters such as linearity, precision, accuracy, specificity, stability, limit of detection and limit ofquantification were studied according to the International Conference on Harmonization Guidelines. Results: Calibration curve was linear between the concentration range of 5-20 μg ml-1. Within- and between-day precision values for atorvastatinwere less than 4.57%, and accuracy (relative error) was better than 3.17%. The mean recovery value of atorvastatinwas 100.1% for pharmaceutical preparations. Conclusion: The developed methods were successfully applied to tablet formulations and the results were compared statistically with each other.

DOI

10.21608/aprh.2018.5824

Keywords

Atorvastatin, First-order derivative spectrophotometry, UV spectrophotometry, validation

Authors

First Name

Bilal

Last Name

Yilmaz

MiddleName

-

Affiliation

Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey

Email

yilmazb@atauni.edu.tr

City

-

Orcid

0000-0002-8574-7570

First Name

Selcuk

Last Name

Kaban

MiddleName

-

Affiliation

Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey

Email

selcukkaban@atauni.edu.tr

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

1044

Issue Date

2018-04-01

Receive Date

2017-11-16

Publish Date

2018-04-01

Page Start

89

Page End

94

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 2_Issue 2_Pages 89-94.pdf

PDF . 397.9kB

Link

https://aprh.journals.ekb.eg/article_5824.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=5824

Order

2

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023