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5829

Antiviral Nucleoside and Nucleotide Analogs: A Review

Article

Last updated: 22 Jan 2023

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Abstract

Virus infections are an increasing and probably lasting global risk. Nucleoside and nucleotide analogs represent the largest class of antiviral drugs. Early success in the treatment of human immunodeficiency virus infection and the recent approval of sofosbuvir as phosphoramidate nucleoside prodrug for chronic hepatitis C have provided proof of concept for important this class of compounds as an antiviral agent. This review summarizes the antiviral activity of nucleoside and nucleotide analogs and their recent application.

DOI

10.21608/aprh.2018.5829

Keywords

Antiviral, Ebola virus, HCV, Nucleoside, Nucleotide, Zika Virus

Authors

First Name

Sawsan

Last Name

Mahmoud

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo, 11795, Egypt

Email

sawsansf@yahoo.com

City

-

Orcid

-

First Name

Sherifa

Last Name

Hasabelnaby

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo, 11795, Egypt

Email

sherifajanaa@yahoo.com

City

-

Orcid

-

First Name

Sherif

Last Name

Hammad

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo, 11795, Egypt

Email

-

City

-

Orcid

-

First Name

Tamer

Last Name

Sakr

MiddleName

-

Affiliation

Radioactive Isotopes and Generator Department, Hot Labs Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt, Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA), Giza, Egypt

Email

tamer_sakr78@yahoo.com

City

-

Orcid

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Volume

2

Article Issue

2

Related Issue

1044

Issue Date

2018-04-01

Receive Date

2018-01-10

Publish Date

2018-04-01

Page Start

73

Page End

88

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 2_Issue 2_Pages 73-88.pdf

PDF . 895.8kB

Link

https://aprh.journals.ekb.eg/article_5829.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=5829

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Type

Review Article

Type Code

358

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Details

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Article

Created At

22 Jan 2023