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4835

Preparation, Biodistribution of 99mTc-Azacytidine Complex as a Potential Agent for Radiotherapy

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Last updated: 03 Jan 2025

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Abstract

Objectives: This study aimed at exploring the possibility of radiolabeling 5-Azacytidine with technetium-99m (99mTc) as a surrogate for Rhenium- 186/188 in order to explore the possibility of using the radiolabeled complex as a targeted radiotherapeutic agent. Methods: Radiolabeling of 5-Azacytidine with 99mTc via complexation reaction using stannous chloride dihydrate as a reducing agent. The biodistribution of the formed complex was then studied in tumour bearing mice. Results: Successful radiolabeling of 5-Azacytidine with 99mTc was achieved with radiolabeling yield 84.94%. The formed complex showed in vitro stability up to 60 min post labelling. The biodistribution study of the complex showed a Target /Non-target ratio of 2.27 at 2h post injection suggesting good localization of the complex. Conclusion: The radiolabeling of 5-Aza was successfully achieved with 99mTc. The biodistribution study in tumour bearing mice showed good localization of the radiolabeled complex at the tumour site, however further studies are needed for achieving better targeting of the complex.

DOI

10.21608/aprh.2018.4835

Keywords

5-azacytidine, Biodistribution, Radiolabeling, Radiochemotherapy, 99mTc

Authors

First Name

Wafaa

Last Name

Zaghary

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Cairo11795, Egypt

Email

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City

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Orcid

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First Name

Mohammed

Last Name

Motaleb

MiddleName

A.

Affiliation

Labelled Compounds Department, Hot Lab Centre, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

Email

mamotaleb10@yahoo.com

City

-

Orcid

-

First Name

Ismail

Last Name

Ibrahim

MiddleName

T.

Affiliation

Labelled Compounds Department, Hot Lab Centre, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

Email

ismailtaha_73@yahoo.com

City

-

Orcid

-

First Name

Mona

Last Name

Sarhan

MiddleName

O.

Affiliation

Labelled Compounds Department, Hot Lab Centre, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

Email

monasarhan@windowslive.com

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-

Orcid

-

Volume

2

Article Issue

1

Related Issue

824

Issue Date

2018-01-01

Receive Date

2017-09-25

Publish Date

2018-01-01

Page Start

63

Page End

72

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 2_Issue 1_Pages 63-72.pdf

PDF . 396.6kB

Link

https://aprh.journals.ekb.eg/article_4835.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=4835

Order

7

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

MainTitle

Preparation, Biodistribution of 99mTc-Azacytidine Complex as a Potential Agent for Radiotherapy

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Article

Created At

22 Jan 2023