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Study II on Chrozophora oblongifolia Aerial Parts: Assessment of Antioxidant Activity, Hepatoprotective Activity and Effect on Hypothalamic-gonadal Axis in Adult Male Rats

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Last updated: 03 Jan 2025

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Abstract

Objectives: The present study aimed at the investigation of antioxidant activity, hepatoprotective activity in addition to the effect on hypothalamic-gonadal axis in adult male rat of total methanolic extract and different fractions of Chrozophora oblongifolia aerial parts. Methods: Antioxidant activity was evaluated by DPPH spectrophotometric method, Hepatoprotective activity was evaluated using CCl4 induced liver damage method by measuring serum marker enzymes, SGOT, SGPT and total bilirubin. The effect on hypothalamic-gonadal axis in adult male rats was estimated by measuring serum level of testosterone, follicle stimulating hormone and leutinizing hormone by immune enzymatic assay kit using ELISA reader. Results: The methanol fraction showed highest antioxidant activity followed by total extract and ethyl acetate fraction concentrate, while the methylene chloride and n-hexane fractions showed lowest antioxidant activity. The total methanolic extract in addition to ethyl acetate and methanol fractions exhibited significant decrease in SGOT and SGPT enzymes and total bilirubin, indicating their effectiveness in protecting the liver normal functional status. The total methanolic extract of aerial and fruit parts, each showed marked increase in serum level of total testosterone, follicle stimulating hormone and leutinizing hormone, when administered orally for 28 successive days compared to control group. Conclusion: Total methanol extract of the aerial parts of Chrozophora oblongifolia has significant antioxidant and hepatoprotective activities. Also extract of aerial parts including fruits has increased rat serum level of gonads, suggesting Chrozophora oblongifolia, as a valuable biological source of drugs enhances fertility.

DOI

10.21608/aprh.2018.4881

Keywords

antioxidant, Chrozophora oblongifolia, fertility, Hepatoprotective activity

Authors

First Name

Mohamed

Last Name

Kamel

MiddleName

-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assuit branch, Assuit, Egypt

Email

mohamedramadan@yahoo.com

City

-

Orcid

-

First Name

Alaa

Last Name

Nafady

MiddleName

-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assuit branch, Assuit, Egypt

Email

alaa12nafady@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Hassanein

MiddleName

-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assuit branch, Assuit, Egypt

Email

ahmedcognosy@yahoo.com

City

-

Orcid

-

First Name

Eman

Last Name

Haggag

MiddleName

-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt

Email

eman.g.haggag@pharm.helwan.edu.eg

City

-

Orcid

-

Volume

2

Article Issue

1

Related Issue

824

Issue Date

2018-01-01

Receive Date

2017-11-14

Publish Date

2018-01-01

Page Start

56

Page End

62

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 2_Issue 1_Pages 56-62.pdf

PDF . 239.9kB

Link

https://aprh.journals.ekb.eg/article_4881.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=4881

Order

6

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

MainTitle

Study II on Chrozophora oblongifolia Aerial Parts: Assessment of Antioxidant Activity, Hepatoprotective Activity and Effect on Hypothalamic-gonadal Axis in Adult Male Rats

Details

Type

Article

Created At

22 Jan 2023