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4832

Pyrrolopyrimidine: A Versatile Scaffold for Construction of Targeted Anti-cancer Agents

Article

Last updated: 03 Jan 2025

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Abstract

Pyrrolopyrimidine derivatives comprise a class of biologically active heterocyclic compounds that are well known to play a critical role in pharmaceutical drug design and health care. The pyrrolopyrimidines serve as promising scaffolds that were found in a number of biologically active compounds including antibiotics, anti-inflammatory, anti-viral and anticancer. Researchers were inspired to develop novel pyrrolopyrimidine derivatives for the treatment of Cancer. Currently several pyrrolopyrimidines are available commercially as anticancer drugs.  The present review article offers a detailed account on the development of pyrrolopyrimidine derivatives with anticancer potential with emphasis on their activity as targeted kinase inhibitors.

DOI

10.21608/aprh.2017.4832

Keywords

Anti-cancer, Protein kinases, Pyrrolopyrimidine

Authors

First Name

Mai

Last Name

Adel

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

mai.adel@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Rabah

Last Name

Serya

MiddleName

A. T.

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

rabah@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Deena

Last Name

Lasheen

MiddleName

S.

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

deenalasheen@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Khaled A

Last Name

Abouzid

MiddleName

A. M.

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

Email

-

City

-

Orcid

-

Volume

2

Article Issue

1

Related Issue

824

Issue Date

2018-01-01

Receive Date

2017-11-15

Publish Date

2018-01-01

Page Start

1

Page End

19

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 2_Issue 1_Pages 1-19.pdf

PDF . 519.3kB

Link

https://aprh.journals.ekb.eg/article_4832.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=4832

Order

1

Type

Review Article

Type Code

358

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

MainTitle

Pyrrolopyrimidine: A Versatile Scaffold for Construction of Targeted Anti-cancer Agents

Details

Type

Article

Created At

22 Jan 2023