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4044

Effect of Mannitol on Physical Characters of Lyophilized Fast-Disintegrating Tablets

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Last updated: 22 Jan 2023

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Abstract

Objectives:Fast-disintegrating tablets (FDTs) also known as orally-disintegrating tablets, orodispersible tablets, fast-melting tablets, rapid-melt tablets are a relatively new dosage form. They are tablets that when placed in the mouth, disintegrate upon coming in contact with the saliva without further need for water or chewing to be swallowed. In order to achieve fast disintegration, tablets are formulated to be highly porous, which unfortunately greatly reduces the mechanical strength of the tablets. The main challenge in formulating FDTs is achieving a balance between fast disintegration and good mechanical strength. Methods: The formulation of, lyophilized fast-disintegrating tablets (LFDTs) is comprised of mainly a binder e.g. gelatin, a lyoprotectant as glycine, as well as mannitol a bulking agent and disintegration enhancer for the manufacture of LFDTs. The effect of mannitol concentration on physical characters of LFDTs, namely, friability, hardness and in-vitro disintegration time was investigated over the range of 10% to 70% w/v. Design-Expert® software v.7 (Stat-Ease Inc., Minneapolis, MN, USA) was used to analyze the obtained results. Results: It was observed that increasing mannitol concentration enhanced the mechanical properties of the LFDTs. Where, it decreased friability and increased hardness. The relationship between mannitol concentration and the in-vitro disintegration time was found to be parabolic. Conclusion: The study encouraged 40% w/v as an optimum concentration of mannitol for ultimate LFDTs formulation.

DOI

10.21608/aprh.2017.4044

Keywords

Fast-disintegrating tablet, Lyophilized tablet, Mannitol, Optimization of LFDTs, Physical characters of LFDTs

Authors

First Name

Samia

Last Name

Omar

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Helwan University, Cairo, Egypt.

Email

omarsamia3@hotmail.com

City

-

Orcid

-

First Name

Fathy

Last Name

AbdAlla

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt. , Department of Pharmaceutics and Pharmaceutical Technology, Egyptian Russian University (ERU), Bader City, Cairo, Egypt

Email

fathyfet@yahoo.com

City

-

Orcid

-

First Name

Noha

Last Name

Abdelgawad

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Helwan University, Cairo, Egypt.

Email

nohamnj@gmail.com

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-

Orcid

-

Volume

1

Article Issue

4

Related Issue

691

Issue Date

2017-10-01

Receive Date

2017-09-19

Publish Date

2017-10-01

Page Start

228

Page End

233

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 1_Issue 4_Pages 228-233.pdf

PDF . 520.9kB

Link

https://aprh.journals.ekb.eg/article_4044.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=4044

Order

7

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023