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4043

Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted Benzo[h]quinazolines, Benzo[h]quinolines and Naphthaleno[d]thiazoles

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Last updated: 22 Jan 2023

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Abstract

Three series of ring-equivalent tricyclic benzo[h]quinazolines, benzo[h]quinolines and naphthaleno[d]thiazoles analogs were designed as bioisosteres and synthesized. The chemical structures of the synthesized agents were elucidated based on their spectral data and elemental analyses. The antimicrobial activity of some of the synthesized compounds was screened and only2-bromo derivative IX and aminothiazole compound X exhibited broad antimicrobial effectiveness. The antifungal MIC value of Xwas1.85 mg/mL.

DOI

10.21608/aprh.2017.4043

Keywords

Antimicrobial, Benzo[h]quinazolines, Benzo[h]quinolones, Naphthaleno[d]thiazoles

Authors

First Name

Mohammed

Last Name

Ebied

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Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

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First Name

Wafaa

Last Name

Zaghary

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-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

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Orcid

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First Name

Kamelia

Last Name

Amin

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-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, Egypt.

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Orcid

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First Name

Sherif

Last Name

Hammad

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-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, Egypt.

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Volume

1

Article Issue

4

Related Issue

691

Issue Date

2017-10-01

Receive Date

2017-07-25

Publish Date

2017-10-01

Page Start

216

Page End

227

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 1_Issue 4_Pages 216-227.pdf

PDF . 688.1kB

Link

https://aprh.journals.ekb.eg/article_4043.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=4043

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6

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023