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4041

Characterization of Degradation Products Resulted from Acidic Hydrolysis of Lisinopril Under Drastic Conditions

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Last updated: 22 Jan 2023

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Abstract

Four degradation products resulted from acidic hydrolysis of lisinopril under drastic conditions. The degradation products were detected by means of ultra-performance liquid chromatography coupled with mass/mass spectroscopy (LC-MS/MS) with simple and sensitive method suitable for LC-MS/MS analysis. The fragmentation behaviors of lisinopril and degradation products were investigated. Two degradation products were described in E.Ph.(8th) as impurities. Both of 6-amino-2-((1-carboxy-3-phenylpropyl)amino) hexanoic acid  (m/z 309+)and 1-(2,6-diaminohexanoyl)pyrrolidine-2-carboxylic acid (m/z 244+) were formed and identified.

DOI

10.21608/aprh.2017.4041

Keywords

Lisinopril analysis, Degradation products, LC-MS/MS, Chemical structure elucidation

Authors

First Name

Eman

Last Name

El-Leithy

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6thof October, Giza, Egypt. , 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, AinHelwan, Cairo, Egypt

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Orcid

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First Name

Gena

Last Name

El-Fiky

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6thof October, Giza, Egypt. , Pharmaceutical Technology Devision, National Research Center, El-Dokki, Giza, Egypt.

Email

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City

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Orcid

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First Name

Mohamed

Last Name

Nabil

MiddleName

-

Affiliation

10th of Ramadan for Pharmaceutical and DiagnosticReagents, 6thof October, Giza, Egypt.

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Volume

1

Article Issue

4

Related Issue

691

Issue Date

2017-10-01

Receive Date

2017-07-13

Publish Date

2017-10-01

Page Start

201

Page End

208

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 1_Issue 4_Pages 201-208.pdf

PDF . 935.7kB

Link

https://aprh.journals.ekb.eg/article_4041.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=4041

Order

4

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023