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Sensitive Spectrophotometric Determination of Atorvastatin in Pharmaceutical Formulation by Ion Pair Complexation with Pararosaniline Hydrochloride

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Last updated: 03 Jan 2025

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Abstract

Objectives: A sensitive visible spectrophotometric method was developed for the determination of atorvastatin in tablet dosage form. Methods: Atorvastatin (ASN) has a free carboxylic moiety in its structure, which when being deprotonated in basic buffered medium facilitates its ion pairing with the cationic pararosaniline dye. Results: The red colored ion pair is easily extractable in organic solvent and exhibits maximum absorption at 547 nm. Different factors affecting the formation of the ion pair and its stability were studied and optimized in order to obtain the best conditions for the experiment. Method validation was done over a concentration range of 1 to 8 µg/mL. The method was proven to be sensitive with limit for quantitation of 0.93 µg/mL and limit of detection of 0.31 µg/mL. Conclusion: The proposed method was easily and successfully applied for the quantitative determination of atorvastatin in commercial tablets without interference from extractable tablet additives. The sensitivity and cheapness of the method will encourage its use in routine quality control of atorvastatin tablets.

DOI

10.21608/aprh.2017.4040

Keywords

Atorvastatin, Ion pair complexation, Pararosaniline HCl, Spectrophotometry, pharmaceutical formulation

Authors

First Name

Ali

Last Name

Alshabrawy

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt

Email

ali.alshabrawy@pharm.helwan.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Mostafa

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt

Email

ahmead34@yahoo.com

City

-

Orcid

-

First Name

Nageh

Last Name

Abotaleb

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt

Email

-

City

-

Orcid

-

Volume

1

Article Issue

4

Related Issue

691

Issue Date

2017-10-01

Receive Date

2017-06-11

Publish Date

2017-10-01

Page Start

193

Page End

200

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 1_Issue 4_Pages 193-200.pdf

PDF . 848.7kB

Link

https://aprh.journals.ekb.eg/article_4040.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=4040

Order

3

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

MainTitle

Sensitive Spectrophotometric Determination of Atorvastatin in Pharmaceutical Formulation by Ion Pair Complexation with Pararosaniline Hydrochloride

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Article

Created At

22 Jan 2023