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4038

Development and Validation of Spectrophotometric Methods for Quantitative Estimation of Oxfendazole in Presence of Its Alkali-induced Degradation Product: A Comparative Study

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Last updated: 22 Jan 2023

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Abstract

Objectives:This study aimed to develop and validate three simple, accurate, selective, reproducible and sensitive spectrophotometric methods for the determination of oxfendazole in the presence of its alkali-induced degradation product without preliminary separation. Methods: (A) first derivative spectrophotometry (1D) method at 298.9 nm, (B) first derivative of ratio spectra (1DD) method at 295.4 nm and (C) area under the curve (AUC) method at wavelength ranges of (290-294 nm) and (297-301 nm). All methods were applied in the range of (1-10µg mL-1). Results: These methods were validated and successfully applied for determination of oxfendazole in Unifendazole® suspension. The obtained results were statistically compared with those of the reported method by applying t-test and F-test at 95% confidence level and no significant difference was observed regarding accuracy and precision.Conclusion: The proposed methods are simple, rapid, economic, accurate and precise to determine oxfendazole in the presence of its alkali-induced degradation product without previous separation steps.

DOI

10.21608/aprh.2017.4038

Keywords

Oxfendazole, Alkaline degradation, Area under curve, Derivative ratio spectra, derivative spectrophotometry

Authors

First Name

Fathy

Last Name

Salama

MiddleName

M

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

fathysalama77@gmail.com

City

-

Orcid

-

First Name

Khalid

Last Name

Attia

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

dr.khalid64@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Mohamad

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Ragab

Last Name

Said

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

ragabmsaid@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Madkour

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

ahmedmadkour8@yahoo.com

City

-

Orcid

-

Volume

1

Article Issue

4

Related Issue

691

Issue Date

2017-10-01

Receive Date

2017-03-29

Publish Date

2017-10-01

Page Start

176

Page End

184

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 1_Issue 4_Pages 176-184.pdf

PDF . 1.2MB

Link

https://aprh.journals.ekb.eg/article_4038.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=4038

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Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023