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3359

Simultaneous UV Spectrophotometric Determination of Pravastatin Sodium and Pioglitazone Hydrochloride in Pharmaceutical Preparations

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Last updated: 22 Jan 2023

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Abstract

Objectives: This study aimed to develop simple UV spectrophotometric methods for simultaneous determination of pravastatin sodium and pioglitazone hydrochloride without previous separation. Methods. The first method is the first derivative, where the peak amplitudes of first derivative of absorption spectra were measured at 249.7 and 277 nm for pravastatin sodium and pioglitazone hydrochloride respectively. The second method is the first derivative of the ratio spectra, where the peak amplitudes were measured at 249.6 and 276.6 nm for pravastatin sodium and pioglitazone hydrochloride respectively. Results. The proposed methods were validated according to International Conference on Harmonization (ICH) guidelines and successfully applied for simultaneous determination of both drugs in their combined dosage form. Conclusion. The proposed methods are simple, rapid, economic, accurate and precise to simultaneously determine pravastatin and pioglitazone in pure form and in pharmaceutical dosage form without previous separation steps.
 

DOI

10.21608/aprh.2017.3359

Keywords

Pravastatin sodium, Pioglitazone Hydrochloride, First derivative, Ratio derivative

Authors

First Name

Ahmed

Last Name

El-Olemy

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt

Email

ahmed_olemy2000@yahoo.com

City

nasr city

Orcid

-

Volume

1

Article Issue

3

Related Issue

599

Issue Date

2017-07-01

Receive Date

2017-04-01

Publish Date

2017-07-01

Page Start

143

Page End

149

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 1_Issue 3_Pages 143-149.pdf

PDF . 632.9kB

Link

https://aprh.journals.ekb.eg/article_3359.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=3359

Order

2

Type

Research Article

Type Code

318

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Article

Created At

22 Jan 2023