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Synthesis and Biological Value of Thiouracils and Fused Thiouracils (A review)

Article

Last updated: 22 Jan 2023

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Abstract

A literature survey revealed that the thiouracil derivatives and their condensed heterocycles have occupied a marked position as synthon for various biologically active compounds. They have a wide range of therapeutic uses that include anti-cancer, anti-microbial, molluscicidal, anti-leishmanial, anti-oxidant, anti-viral as anti-HIV and anti-HCV, and anti-thyroid activities. Numerous methods for the synthesis of thiouracils offer enormous scope in the field of medicinal chemistry. The review article aims to review the work reported for the synthesis and the biological activities of thiouracils and fused thiouracils from the past to recent years.

DOI

10.21608/aprh.2017.1970

Keywords

biological activities, Fused thiouracils, Synthesis, Thiouracils

Authors

First Name

Mosad

Last Name

Sayed

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Helwan University, Ein-Helwan, Cairo, Egypt

Email

doctormosaad@hotmail.com

City

Cairo

Orcid

-

First Name

Naglaa

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Helwan University, Ein-Helwan, Cairo, Egypt

Email

nogamoon2005@yahoo.com

City

Cairo

Orcid

-

Volume

1

Article Issue

2

Related Issue

419

Issue Date

2017-04-01

Receive Date

2017-01-25

Publish Date

2017-04-01

Page Start

75

Page End

88

Print ISSN

2357-0547

Online ISSN

2357-0539

Article File

APRH_Volume 1_Issue 2_Pages 75-88.pdf

PDF . 730.0kB

Link

https://aprh.journals.ekb.eg/article_1970.html

Detail API

https://aprh.journals.ekb.eg/service?article_code=1970

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1

Publication Type

Journal

Publication Title

Journal of Advanced Pharmacy Research

Publication Link

https://aprh.journals.ekb.eg/

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Details

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Article

Created At

22 Jan 2023