Novel furan-2-one and pyrazole heterocycles incorporating 5,6,7,8-tetrahydronaphthalene moiety 4, 8, 10a-c, 12a-c and 13 were prepared starting from 2-acetyl tetralin via reaction with diethyl oxalate followed by cyclization using hydroxylamine hydrochloride, and hydrazine hydrate. Further treatment of carbohydrazide 8 with isatin derivatives 9a-c and hydrazonoyl halides 11a-c afforded N'-(5-subs.-2-oxoindolin-3-ylidene)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazole-5-carbohydrazides 10a-c and N'-aryl-2-(2-(3-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazole-5-carbonyl)hydrazono)propanehydrazonoyl chlorides 12a-c. The novel compounds were examined in vitro for their anti-tumor activities against HepG-2 and MCF-7 human carcinoma cell lines using MTT assay. Most compounds showed good to moderate activities against HepG-2 carcinoma cells and HepG-2 cells.