Several pyrazoles with various substitutions at various positions were prepared starting from pyrazole and its derivatives. The biological activities of newly synthesized compounds were tested and evaluated in vivo and vitro for different types of diseases and showed good results, in addition to some examples of some pyrazoles Containing heterocycles were established as drugs such as Celecoxib Lesopitron Sulfaphenazole Rimonabant Tebufenpyrad Betazole Tepoxalin Pyriprole Deracoxib Mavacoxib. Pyrazole (1,2-Diazole). It is a heterocyclic aromatic organic compound with a 5-membered ring of three carbon atoms and two adjacent nitrogen centers with the molecular formula C3H4N2 ; molar mass, 68.08 g mol−1; melting point, 66–70 °C, boiling point, 186–188 °C ; basicity (pKb), 2.5