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230637

Synthesis and Biological Activity of Chromene Derivatives, chromeno[2,3-d][1,3]oxazine derivatives, and chromeno[2,3-d]pyrimidine derivatives

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

Chromene derivative 1 reacted with acetyl chloride and chloroacetyl chloride to give compounds 2a,b. Acetyl derivatives 2a,b were heated under reflux in dry xylene to give oxazine derivatives 3a,b which reacted with hydrazine hydrate and hydroxylamine to afford compounds 4a,b and 5a,b respectively. Pyrimidine derivative 4a reacted with xylose and glucose to give compounds 6a,b which were converted to compounds 7a,b by reaction with acetic anhydride. The structure of the prepared derivatives was elucidated through mass spectroscopy, 1H & 13C NMR, infrared spectroscopy and elemental analysis. Anticancer activity of some of prepared compounds was performed against three different cancer cell lines.

DOI

10.21608/ejchem.2022.114873.5214

Keywords

Chromene, chromeno[2, 3-d][1, 3]oxazin, oxazine, Anticancer activity

Authors

First Name

Mahmoud

Last Name

Yousif

MiddleName

Nabil Mahmoud

Affiliation

Department of Photochemistry, National Research Centre, Cairo, Egypt

Email

mahmoud_nabil18@yahoo.com

City

-

Orcid

-

First Name

Reda

Last Name

Abdelhameed

MiddleName

M.

Affiliation

Department of Applied Organic Chemistry, Chemical Industries Research Institute, National Research Centre, Egypt

Email

reda_nrc@yahoo.com

City

-

Orcid

-

First Name

Ameen

Last Name

Abu-Hashem

MiddleName

A

Affiliation

Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Cairo, Egypt

Email

aminaliabuhashem@yahoo.com

City

-

Orcid

-

First Name

Nabil

Last Name

Yousif

MiddleName

M.

Affiliation

Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Cairo, Egypt

Email

profnabil_2013@yahoo.com

City

-

Orcid

-

Volume

66

Article Issue

1

Related Issue

38521

Issue Date

2023-01-01

Receive Date

2022-01-05

Publish Date

2023-01-01

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_230637.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=230637

Order

230,637

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis and Biological Activity of Chromene Derivatives, chromeno[2,3-d][1,3]oxazine derivatives, and chromeno[2,3-d]pyrimidine derivatives

Details

Type

Article

Created At

22 Jan 2023