The use of medicinal plants dates from ancient times. Humans learned to seek therapy in the barks, leaves, fruits, flowers, and other parts of plants as a result of many years of struggles against illnesses. Gliricidia sepium (Jacq.) Kunth. ex. Walp., is one of the most important plants in pharmacognosy and medicine fields because it serves as a reservoir for potent bioactive compounds such as saponins, flavonoids, volatile oils, and other bioactive compounds that have been extracted from various parts of it. Gliricidia sepium is the topic of much research due to its numerous traditional applications, which include treating coughs, asthma, curing urticaria, rash, burns, scabies, dermatitis, acting as an antipruritic on the skin, and treating bacterial and protozoal infections. Many medicinal uses for Gliricidia sepium have been discovered over time, including cytotoxic activity, anti-microbial activity, anti-bacterial activity, anti-inflammatory activity, antioxidant activity, thrombolytic anti-sickling activity, wound healing, mosquitocidal activity, and anthelmintic activity.