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229663

Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Organic chemistry

Abstract

Some novel enantiopure 3-carboxylic isoxazolidine derivatives were synthesized by stereocontrol 1,3-dipolar cycloaddition (1,3-DC) between nitrone derived (-)-menthone with alkenes derived from phenol and benzyl alcohol. Furthermore, the synthesized molecules were optimized for their drug-likeness and pharmacokinetics parameters by using in silico methods.

DOI

10.21608/ejchem.2022.126231.5597

Keywords

isoxazolidines, enantiopure, chiral nitrone, drug-likeness, Pharmacokinetics

Authors

First Name

Mejdi

Last Name

Snoussi

MiddleName

-

Affiliation

University of Hail, KSA

Email

snmejdi@yahoo.fr

City

-

Orcid

0000-0002-2309-2601

First Name

Ameni

Last Name

Ghabi

MiddleName

-

Affiliation

University of Monastir

Email

gabi1980a31@yahoo.com

City

-

Orcid

-

First Name

Magdy

Last Name

abid

MiddleName

El-Sadek

Affiliation

Chemistry Department, College of Sciences & Art, . Jouf University, Saudi Arabia

Email

mabid@ju.edu.sa

City

-

Orcid

-

First Name

Abdullah

Last Name

Althunayyan

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah 51452, Saudi Arabia

Email

391100388@qu.edu.sa

City

-

Orcid

-

First Name

Azda

Last Name

Alassaf

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia

Email

azdahalassaf@hotmail.com

City

-

Orcid

-

First Name

Fahad

Last Name

Alminderej

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia

Email

f.alminderej@qu.edu.sa

City

-

Orcid

-

First Name

Abuzar

Last Name

E. A. E. Albadria

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia

Email

as.albadri@qu.edu.sa

City

-

Orcid

-

First Name

Wael A.

Last Name

El-Sayed

MiddleName

-

Affiliation

Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt

Email

waelshendy@gmail.com

City

-

Orcid

-

First Name

Adel

Last Name

Kadri

MiddleName

-

Affiliation

Faculty of Science of Sfax, Department of Chemistry, University of Sfax, B.P. 1171, 3000 Sfax, Tunisia.

Email

lukadel@yahoo.fr

City

-

Orcid

-

First Name

Kais

Last Name

Aouadi

MiddleName

-

Affiliation

Department of Chemistry, College of Science, Qassim University, buraidah

Email

kaiss_aouadi@hotmail.com

City

-

Orcid

-

Volume

66

Article Issue

1

Related Issue

38521

Issue Date

2023-01-01

Receive Date

2022-03-08

Publish Date

2023-01-01

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_229663.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=229663

Order

229,663

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023