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228187

Synthesis and physicochemical characterization of Schiff base complexes and examination of their selectivity index for breast and colon cancer cells.

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

The present investigation relates to the new method of preparing schiff base of 4-(2-Hydroxy-1,2-diphenyl-ethylideneamino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one as well as the preparation of metallic compounds with certain ions such as (La(III), Gd(III), Co(II), and Cd (II)) in normal and nano-size and their biological applications of their ability to treat colon and breast cancer cells without affecting normal cells. These synthesized compounds have been characterized using different analytical techniques including physicochemical studies such as elemental analysis, electrical conductivity, Uv-visible, IR, nuclear magnetic resonance (NMR), mass spectrometry, magnetic and thermal studies as well as imagining using transmission electron microscopy (TEM). In vitro, the anti-cancer activity of these synthesized compounds was investigated, and their mechanism of action was detected. The results proved that these compounds have the anti-cancer activity against colon cancer (Caco-2) and breast cancer (MCF-7) cell lines at very low concentrations up to 8.27 mg/ml. It was found that the Cd (II) compound showed the highest selectivity against cancer cells without affecting the normal (Vero) cells with selective index (SI) values about 62 times for breast cancer cells and about 51 times for colon cancer cells.

DOI

10.21608/ejchem.2022.117920.5313

Keywords

Keywords: Schiff base, 4-aminoantipyrine, metallic compounds, physicochemical studies, Anti-cancer activity, apoptosis

Authors

First Name

Rania H.

Last Name

Taha

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, P.O. Box: 11754, Yousef Abbas Str., Nasr City, Cairo, Egypt.

Email

mhmd_mosad@yahoo.com

City

-

Orcid

-

First Name

Esmail

Last Name

El-Fakharany

MiddleName

-

Affiliation

Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research & Technological Applications (SRTA-City), New Borg El-Arab City, P.O. Box: 21934, Alexandria, Egypt.

Email

esmailelfakharany@yahoo.co.uk

City

New Borg El-Arab City

Orcid

0000-0002-0724-8477

First Name

Zienab

Last Name

El-Shafiey

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, P.O. Box: 11754, Yousef Abbas Str., Nasr City, Cairo, Egypt.

Email

z.elshafiey@yahoo.com

City

-

Orcid

-

First Name

Aida

Last Name

Salman

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, P.O. Box: 11754, Yousef Abbas Str., Nasr City, Cairo, Egypt.

Email

a_salman@yahoo.com

City

-

Orcid

-

First Name

Mai

Last Name

Mansour

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, P.O. Box: 11754, Yousef Abbas Str., Nasr City, Cairo, Egypt.

Email

maimansour2003@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Yahia

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Helwan University, Ain-Helwan, 11795 Cairo, Egypt.

Email

yahia_sci@yahoo.com

City

Cairo

Orcid

0000-0001-8915-2921

Volume

66

Article Issue

1

Related Issue

38521

Issue Date

2023-01-01

Receive Date

2022-01-23

Publish Date

2023-01-01

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_228187.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=228187

Order

228,187

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis and physicochemical characterization of Schiff base complexes and examination of their selectivity index for breast and colon cancer cells.

Details

Type

Article

Created At

22 Jan 2023